Fri May 26 2023

34 articles - From Friday May 19 2023 to Friday May 26 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Pancreatology

Predictive ability of pancreatic cyst fluid biomarkers: A systematic review and meta-analysis.

Cyst fluid analysis can be a valuable tool in the characterization of pancreatic cysts, with relevant clinical implications. Our results support the use of DNA-based cyst fluid biomarkers in the multidisciplinary diagnostic work-up of pancreatic cysts.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Different levels of ultra-processed food and beverage consumption and associations with environmental sustainability and all-cause mortality in EPIC-NL.

Reducing UPD consumption could lower environmental impact and all-cause mortality risk, however this was not shown for UPF. When categorizing foods consumption by their degree of processing trade-offs are observed for human and planetary health aspects.

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Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy?

In this cohort of pregnant women reporting widespread use of folic acid supplements, maternal genetic liability to folate deficiency did not significantly influence the ASM-associated risk of impaired neurodevelopment.

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Interrogating components of two diet quality indices in pregnancy using a supervised statistical mixtures approach.

Compared to traditional methods, associations of diet index mixtures with gestational length were more robust and identified unique contributors. Additional studies could consider interrogating these approaches using other indices and health outcomes.

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Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.

Low choline intake was associated with increased risks of incident dementia and AD.

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Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a HEEDS Workshop.

This report details the discussions, key areas of agreement and future opportunities to prevent obesity. The attendees agreed that environmental obesogens are real, significant, and a contributor at some level to weight gain at the individual level and to the global obesity and metabolic disease pandemic at a societal level moreover, it is at least, in theory, remediable.

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Inflamm Bowel Dis

1-Year Comparative Effectiveness of Tofacitinib vs Ustekinumab for Patients With Ulcerative Colitis and Prior Antitumor Necrosis Factor Failure.

In a real-world UC cohort, tofacitinib and ustekinumab demonstrated similar effectiveness at 52 weeks. Adverse events were consistent with the known safety profiles of these agents.

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Alterations in the Fungal Microbiome in Ulcerative Colitis.

Endoscopic inflammation in ulcerative colitis is associated with an expansion of Saccharomyces and Candida compared with remission. The role of these fungal taxa as potential biomarkers and targets for personalized approaches to therapeutics in ulcerative colitis should be evaluated.

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Bedside Intestinal Ultrasound Predicts Disease Severity and the Disease Distribution of Pediatric Patients With Inflammatory Bowel Disease: A Pilot Cross-sectional Study.

Increasing BWT is associated with increasing endoscopic activity in pediatric IBD. Our study suggests that the optimal BWT cutoff value for detecting active disease may be less than that seen in adults. Additional pediatric studies are needed.

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Molecular Pathogenesis of Colitis-associated Colorectal Cancer: Immunity, Genetics, and Intestinal Microecology.

Furthermore, the intestinal microbiota and metabolites have a great impact on IBD and CAC. By clarifying immune, genetic, intestinal microecology, and other related pathogenesis, CAC may be more predictable and treatable.

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Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications.

For example, we observed that colon TH17 cells from vedolizumab nonresponders were predicted to have a greater degree of interactions with classical monocytes compared with responders, whereas colon TH17 cells from vedolizumab responders exhibited more interactions with myeloid dendritic cells compared with nonresponders. Overall, our results indicate that efforts to elucidate cell-cell communications among immune and nonimmune cell types may increase the mechanistic understanding of current and investigational therapies for IBD.

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J Crohns Colitis

A comparative evaluation of the measurement properties of three histological indices of mucosal healing in ulcerative colitis: Geboes Score, Robarts Histopathology Index, and Nancy Index.

The GS, RHI, and NI are each capable of producing reliable and valid scores that are sensitive to changes in disease activity over time, in patients with moderately to severely active ulcerative colitis. While al three indices demonstrated relatively acceptable measurement properties, the GS and RHI performed better than the NI.

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Defining biological remission in Crohn's disease: interest, challenges and future directions.

We discuss the interest of our proposal (guiding treatment maintenance, escalation or de-escalation) but also the fact that its clinical implementation would require overcoming major challenges. Finally, future directions are proposed to better define biological remission.

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Differential effects of ontamalimab versus vedolizumab on immune cell trafficking in intestinal inflammation and IBD.

Ontamalimab has unique and broader mechanisms of action compared to vedolizumab. However, this seems to be compensated by redundant cell trafficking circuits and leads to similar preclinical efficacy of anti-a4ß7 and anti-MAdCAM-1 treatment. These results will be important for the interpretation of pending phase III data.

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Early intervention with biological therapy in Crohn´s disease - how early is early?

Starting anti-TNF therapy within the first 24 months after diagnosis was associated with a low rate of CD-related complications and high rates of clinical and endoscopic remission, although we found no differences with earlier initiation within this window of opportunity.

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Impact of Holding Immunosuppressive Therapy in Patients with Inflammatory Bowel Disease Around mRNA COVID-19 Vaccine Administration on Humoral Immune Response and Development of COVID-19 Infection.

We recommend continuing IBD medications while receiving mRNA COVID-19 vaccination without interruption.

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Patient and Public Involvement in Research: Lessons for Inflammatory Bowel Disease.

A key example of participatory research in IBD is the I-CARE study, a large-scale, pan-European observational study assessing the safety of advanced therapies, which had significant patient involvement throughout the study. In this review, we provide a comprehensive overview of the benefits and challenges of participatory research and discuss opportunities of building strategic alliances between IBD patients, healthcare providers, and academics to strengthen research outcomes.

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Supervised machine learning classifies inflammatory bowel disease patients by subtype using whole exome sequencing data.

We demonstrate promising classification of patients by subtype utilising random forest and WES data. Focussing on specific subgroups of patients, with larger datasets may result in better classification.

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Liver Transpl

Comparison of pure laparoscopic donor right posterior sectionectomy versus right hemihepatectomy for living donor liver transplantation.

The PLDRPS group might be comparable with the PLDRH group based on the surgical outcomes of donors and recipients. However, in terms of recipient outcomes, more careful selection of donor of the RPS graft and further research in a large number of cases are necessary to evaluate the usefulness of PLDRPS.

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Geographic disparities in access to liver transplantation.

We must simultaneously work at the national level to standardize and share patient data (including socioeconomic status and geographic social deprivation indices) to better understand the factors that contribute to geographic disparity. The complex interplay between organ distribution policy, referral patterns and variable waitlisting practices with the proportion of high MELD patients and differences in potential donor supply, must al be considered to create a national policy strategy to address the inequities in the system.

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Pancreatology

Comparative analysis of the sarcopenia and HALP score on postoperative outcomes in pancreatic cancer patients after pancreatoduodenectomy.

In line with the data obtained from our study, HALP score and sarcopenia are among the important parameters used to evaluate postoperative complications and provide information about survival. Patients with a low HALP score and sarcopenic have an increased likelihood of developing postoperative complications and a lower survival.

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Promoter hypermethylation of SFRP1 as a prognostic and potentially predictive blood-based biomarker in patients with stage III or IV pancreatic ductal adenocarcinoma.

Together with existing literature, results could indicate the value of cfDNA-measured phSFRP1 as a predictive biomarker of standard palliative chemotherapy in patients with metastatic PDAC. This could facilitate personalized treatment of patients with metastatic PDAC.

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Risk of pancreatic cancer after acute pancreatitis: A population-based matched cohort study.

The risk of pancreatic cancer increases rapidly after acute pancreatitis diagnosis, gradually declines after 2 years, and remains elevated for up to 10 years. Further studies are needed to determine the long-term effects of acute pancreatitis on the risk of pancreatic cancer.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Breastfeeding and the Obesity Pandemic.

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COP27 Climate Change Conference: urgent action needed for Africa and the world: Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change.

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Inflamm Bowel Dis

3D Imaging and Printing in Inflammatory Bowel Diseases: Limitations, Barriers, and Opportunities Toward "Haute Couture" Surgical Approaches.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Clin Nutr

Challenges and opportunities for mycoprotein-based food products.

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Liver Transpl

Cutting deep: Understanding the risks associated with postoperative infections in patients with cirrhosis.

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Issue Information - Author Checklist.

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Issue Information - Instructions to Authors.

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Letter to the editor: Development of a portable abdominal normothermic regional perfusion (A-NRP) program in the United States.

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MELD 3.0: A better score for liver allocation?

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Reply: Development of a portable abdominal normothermic regional perfusion (A-NRP) program in the united states.

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The next step in frailty assessment: Biomarker development.

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Letters&Replies

Letters to the editors and authors’ replies